Wilder's colleague, paediatrician Mynie Peterman, later formulated the classic diet, with a ratio of one gram of protein per kilogram of body weight in children, 10–15 g of carbohydrate per day, and the remainder of calories from fat. Peterman's work in the 1920s established the techniques for induction and maintenance of the diet. Peterman documented positive effects (improved alertness, behaviour and sleep) and adverse effects (nausea and vomiting due to excess ketosis). The diet proved to be very successful in children: Peterman reported in 1925 that 95% of 37 young patients had improved seizure control on the diet and 60% became seizure-free. By 1930, the diet had also been studied in 100 teenagers and adults. Clifford Barborka, also from the Mayo Clinic, reported that 56% of those older patients improved on the diet and 12% became seizure-free. Although the adult results are similar to modern studies of children, they did not compare as well to contemporary studies. Barborka concluded that adults were least likely to benefit from the diet, and the use of the ketogenic diet in adults was not studied again until 1999.[10][14] The GOSH epilepsy/neurology/metabolic teams can advise the local team on management if required, and can be contacted through the GOSH switchboard, 0207 405 9200. Least liked Turn recording back on My plan provides step-by-step instructions on how to determine your custom and specific macronutrient levels (the amount of fat, protein and carb that you should eat given your physical characteristics). Quick & Easy Ketogenic Cooking Children's Items & Toys Nuts The Report Sign-Up Occasions 9. Puchowicz MA, Xu K, Sun X, et al. Diet-induced ketosis increases capillary density without altered blood blow in rat brain. Am J Physiol Endocrinol Metab. 2007;292:E1607–E1615. [PubMed]

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